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Aconitase 2 (ACO2) Human siRNA Oligo Duplex (Locus ID 50)

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SKU
SR300038
ACO2 (Human) - 3 unique 27mer siRNA duplexes - 2 nmol each
  $518.00
In Stock*

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Other products for "ACO2 or NM_001098"

Specifications
Specifications
Product Data
Purity HPLC purified
Quality Control Tested by ESI-MS
Sequences Available with shipment
Components
ACO2 (Human) - 3 unique 27mer siRNA duplexes - 2 nmol each (Locus ID 50)
Included - SR30004, Trilencer-27 Universal Scrambled Negative Control siRNA Duplex - 2 nmol
Included - SR30005, RNAse free siRNA Duplex Resuspension Buffer - 2 ml
Stability One year from date of shipment when stored at -20°C.
Shipping Ambient
# of Transfections Approximately 330 transfections/2nmol in 24-well plate under optimized conditions (final conc. 10 nM).
Note Single siRNA duplex (10nmol) can be ordered.
Reference Data
RefSeq NM_001098
UniProt ID Q99798
Synonyms ACONM; HEL-S-284; ICRD; OCA8; OPA9
Summary The protein encoded by this gene belongs to the aconitase/IPM isomerase family. It is an enzyme that catalyzes the interconversion of citrate to isocitrate via cis-aconitate in the second step of the TCA cycle. This protein is encoded in the nucleus and functions in the mitochondrion. It was found to be one of the mitochondrial matrix proteins that are preferentially degraded by the serine protease 15(PRSS15), also known as Lon protease, after oxidative modification. provided by RefSeq, Jul 2008
Performance Guaranteed OriGene guarantees that at least two of the three Dicer-Substrate duplexes in the kit will provide at least 70% or more knockdown of the target mRNA when used at 10 nM concentration by quantitative RT-PCR when the TYE-563 fluorescent transfection control duplex (cat# SR30002) indicates that >90% of the cells have been transfected and the HPRT positive control (cat# SR30003) provides 90% knockdown efficiency.

For non-conforming siRNA, requests for replacement product must be made within ninety (90) days from the date of delivery of the siRNA kit. To arrange for a free replacement with newly designed duplexes, please contact Technical Services at techsupport@origene.com. Please provide your data indicating the transfection efficiency and measurement of gene expression knockdown compared to the scrambled siRNA control (quantitative RT-PCR data required).
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Documents
Resources

file-alt Citations

Iron-Sulfur Clusters and Iron Responsive Element Binding Proteins Mediate Iron Accumulation in Corneal Endothelial Cells in Fuchs Dystrophy
Hartness, Shevalye, Skeie et al
Invest Ophthalmol Vis Sci (2025) 66 (4), 23 DOI: 10.1167/iovs.66.4.23
Cited by 4
AI Summary: OriGene products, specifically the FDX1 (SR301559) and ACO2 (SR300038) 27-mer siRNA duplexes and the universal scrambled siRNA negative control (SR30004), were used to selectively silence target genes in cell cultures, enabling the study to assess the impact of these genes on ferroptosis susceptibility in corneal endothelial cells related to Fuchs dystrophy.
Snippet: 1 and ACO2 Knockdown in HCEC-B4G12 Cells Three unique FDX1 (human) 27-mer siRNA duplexes (Cat. no. SR301559) and three unique ACO2 (human) 27-mer siRNA duplexes (Cat. no. SR300038) were obtained from OriGene Technologies (Rockville, MD, USA). A 27-mer universal scrambled siRNA duplex was also procured as the siRNA negative control (Cat. no. SR30004;OriGene). The unique siRNA duplexes against FDX1
FigureFigureFigure
Showing 1-1 of 1 papers.
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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