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Slc30a8 Rat shRNA Plasmid (Locus ID 299903)

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SKU
TR708553
Slc30a8 - Rat, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
2 Weeks*

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Specifications
Specifications
Product Data
Locus ID 299903
Synonyms ZnT-8
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components Slc30a8 - Rat, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 299903). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq NM_001130538, NM_001130538.1
UniProt ID P0CE46
Summary Facilitates the accumulation of zinc from the cytoplasm into intracellular vesicles, being a zinc-efflux transporter (By similarity). May be a major component for providing zinc to insulin maturation and/or storage processes in insulin-secreting pancreatic beta-cells.UniProtKB/Swiss-Prot Function
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

Down-regulation of ZnT8 expression in INS-1 rat pancreatic beta cells reduces insulin content and glucose-inducible insulin secretion
Fu, Tian, Pratt et al
PLoS One (2009) 4 (5), e5679 DOI: 10.1371/journal.pone.0005679
Cited by 85
AI Summary: OriGene’s ZnT8 shRNA (rat) was used in this study to downregulate ZnT8 expression in INS-1 pancreatic beta cells, enabling the researchers to demonstrate that reduced ZnT8 levels lead to lower insulin content and impaired glucose-stimulated insulin secretion.
FigureFigureFigure
Showing 1-1 of 1 papers.
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