Ufm1 Mouse shRNA Plasmid (Locus ID 67890)
Specifications
| Product Data | |
| Locus ID | 67890 |
|---|---|
| Synonyms | 1810045K17Rik; AI132708; AI463323; ENSMUSG00000074598; Gm10726 |
| Vector | pRS |
| E. coli Selection | Ampicillin |
| Mammalian Cell Selection | Puromycin |
| Format | Retroviral plasmids |
| Components | Ufm1 - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 67890). 5µg purified plasmid DNA per construct29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free. |
| RefSeq | BC061065, NM_026435, NM_026435.1, NM_026435.2, NM_026435.3, NM_026435.4, NM_026435.5, BC033280, BC051554 |
| UniProt ID | P61961 |
| Summary | Ubiquitin-like modifier which can be covalently attached via an isopeptide bond to substrate proteins as a monomer or a lysine-linked polymer (PubMed:21494687). The so-called ufmylation, requires the UFM1-activating E1 enzyme UBA5, the UFM1-conjugating E2 enzyme UFC1, and the UFM1-ligase E3 enzyme UFL1. This post-translational modification on lysine residues of proteins may play a crucial role in a number of cellular processes. TRIP4 ufmylation may for instance play a role in nuclear receptors-mediated transcription (By similarity). Other substrates may include DDRGK1 with which it may play a role in the cellular response to endoplasmic reticulum stress.UniProtKB/Swiss-Prot Function |
| shRNA Design | These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service. |
| Storage | Store at -20°C |
| Shipping | Ambient |
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