Spdya Mouse shRNA Plasmid (Locus ID 70891)
Specifications
| Product Data | |
| Locus ID | 70891 |
|---|---|
| Synonyms | 4921517J08Rik; 4930548B21Rik; GS4; MLZ-465; Spdy1 |
| Vector | pRS |
| E. coli Selection | Ampicillin |
| Mammalian Cell Selection | Puromycin |
| Format | Retroviral plasmids |
| Components | Spdya - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 70891). 5µg purified plasmid DNA per construct29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free. |
| RefSeq | NM_001142631, NM_029254, NM_029254.1, NM_001142631.1, BC147706, BC147719 |
| UniProt ID | Q5IBH7 |
| Summary | Regulates the G1/S phase transition of the cell cycle by binding and activating CDK1 and CDK2 (PubMed:15611625). Contributes to CDK2 activation without promoting CDK2 phosphorylation, by inducing a conformation change of the CDK2 T-loop that obstructs the substrate-binding cleft prior to kinase activation. Interferes with CDKN1B-mediated inhibition of CDK2. Mediates cell survival during the DNA damage process through activation of CDK2 (By similarity).UniProtKB/Swiss-Prot Function |
| shRNA Design | These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service. |
| Storage | Store at -20°C |
| Shipping | Ambient |
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