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Mdc1 Mouse shRNA Plasmid (Locus ID 240087)

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SKU
TR517490
Mdc1 - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
2 Weeks*

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Specifications
Specifications
Product Data
Locus ID 240087
Synonyms 6820401C03; AA413496; mKIAA0170; NFBD; Nfbd1
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components Mdc1 - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 240087). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq NM_001010833, NM_001010833.1, NM_001010833.2, BC085140, BC094363
UniProt ID Q5PSV9
Summary The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 7 divergent copies of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci. Mice with mutations in this gene exhibit growth retardation, male infertility, immune defects, chromosome instability, DNA repair defects, and radiation sensitivity. provided by RefSeq, Jul 2008
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

BRCT-domain protein BRIT1 influences class switch recombination
Yen, Chaudhry, Vaidyanathan et al
PNAS (2017)
AI Summary: OriGene’s shRNAs against mouse MDC1 (catalog TG517490) were used to deplete MDC1 and assess its role in class switch recombination in BRIT1-deleted B cells.
Snippet: All 5 versions Cite SaveSaving...;he shRNAs (sh3 and sh4) against mouse MDC1 were obtained from Origene (TG517490). Target sequences are listed in Table S3
Showing 1-1 of 1 papers.
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