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Pdk1 Mouse shRNA Plasmid (Locus ID 228026)

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SKU
TR517458
Pdk1 - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
2 Weeks*

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Specifications
Specifications
Product Data
Locus ID 228026
Synonyms B830012B01; D530020C15Rik
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components Pdk1 - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 228026). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq BC027196, NM_172665, NM_001360002, NM_172665.1, NM_172665.2, NM_172665.3, NM_172665.4, NM_172665.5, BC025480
UniProt ID Q8BFP9
Summary Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Plays an important role in cellular responses to hypoxia and is important for cell proliferation under hypoxia. Protects cells against apoptosis in response to hypoxia and oxidative stress (By similarity).UniProtKB/Swiss-Prot Function
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

Early TCR Signaling Induces Rapid Aerobic Glycolysis Enabling Distinct Acute T Cell Effector Functions
Menk, Scharping, Moreci et al
Cell Rep (2018) 22 (6), 1509-1521 DOI: 10.1016/j.celrep.2018.01.040
AI Summary: OriGene contributed shRNA retroviral constructs to this study, which were used to transduce OT-I T cells for gene knockdown experiments investigating the regulation of aerobic glycolysis during T cell activation.
Snippet: Short hairpin RNA (shRNA) retroviral constructs were purchased from OriGene, and OT-I T cells were transduced as previously described (Scharping et al., 2016), except that puromycin (2 µg/mL) was used for selection
FigureFigureFigure
Showing 1-1 of 1 papers.
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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