Ttc26 Mouse shRNA Plasmid (Locus ID 264134)
Specifications
| Product Data | |
| Locus ID | 264134 |
|---|---|
| Synonyms | 9330141E21Rik; 9430097H08Rik; hop; hpy |
| Vector | pRS |
| E. coli Selection | Ampicillin |
| Mammalian Cell Selection | Puromycin |
| Format | Retroviral plasmids |
| Components | Ttc26 - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 264134). 5µg purified plasmid DNA per construct29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free. |
| RefSeq | BC066060, NM_153600, NM_153600.1, NM_153600.2, BC031513, BC066087 |
| UniProt ID | Q8BS45 |
| Summary | Component of the intraflagellar transport (IFT) complex B required for transport of proteins in the motile cilium. Required for transport of specific ciliary cargo proteins related to motility, while it is neither required for IFT complex B assembly or motion nor for cilium assembly. Required for efficient coupling between the accumulation of GLI2 and GLI3 at the ciliary tips and their dissociation from the negative regulator SUFU (PubMed:22718903, PubMed:25340710). Plays a key role in maintaining the integrity of the IFT complex B and the proper ciliary localization of the IFT complex B components. Not required for IFT complex A ciliary localization or function. Essential for maintaining proper microtubule organization within the ciliary axoneme (PubMed:28264835).UniProtKB/Swiss-Prot Function |
| shRNA Design | These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service. |
| Storage | Store at -20°C |
| Shipping | Ambient |
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