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Tgfbr2 Mouse shRNA Plasmid (Locus ID 21813)

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SKU
TR516186
Tgfbr2 - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
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Specifications
Specifications
Product Data
Locus ID 21813
Synonyms 1110020H15Rik; AU042018; DNIIR; RIIDN; TbetaR-II; TbetaRII; TBR-II
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components Tgfbr2 - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 21813). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq BC052629, NM_009371, NM_029575, NM_009371.1, NM_009371.2, NM_009371.3, NM_029575.2, NM_029575.3, BC016262
UniProt ID Q62312
Summary Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways (By similarity).UniProtKB/Swiss-Prot Function
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

TGF-β Signaling Regulates Cementum Formation through Osterix Expression
Choi, Ahn, Kim et al
Sci Rep (2016) 6, 26046 DOI: 10.1038/srep26046
Cited by 44
AI Summary: In this study, the full-length mouse Osx (Osterix) cDNA clone in the pCMV6 vector from OriGene Technologies was used to transduce OCCM-30 cells and investigate the role of Osx in cementoblast differentiation and cementum formation.
Snippet: Transfection and retroviral transduction. The full length open reading frame of mouse Osx (Accession No. NM_130458), cloned into the pCMV6 vector, was purchased from OriGene Technologies. A GFP construct was also transfected as a control. ... Cite SaveSaving
FigureFigureFigure
Showing 1-1 of 1 papers.
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