Hsph1 Mouse shRNA Plasmid (Locus ID 15505)
Specifications
| Product Data | |
| Locus ID | 15505 |
|---|---|
| Synonyms | 105kDa; AI790491; hsp-E7I; Hsp105; Hsp110; hsp110/105 |
| Vector | pRS |
| E. coli Selection | Ampicillin |
| Mammalian Cell Selection | Puromycin |
| Format | Retroviral plasmids |
| Components | Hsph1 - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector (Gene ID = 15505). 5µg purified plasmid DNA per construct29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free. |
| RefSeq | BC018378, NM_001347534, NM_013559, NM_013559.1, NM_013559.2 |
| UniProt ID | Q61699 |
| Summary | Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering client/substrate protein release (By similarity). Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities (PubMed:14644449, PubMed:15292236).UniProtKB/Swiss-Prot Function |
| shRNA Design | These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service. |
| Storage | Store at -20°C |
| Shipping | Ambient |
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