Tiam2 Mouse shRNA Plasmid (Locus ID 24001)
Specifications
| Product Data | |
| Locus ID | 24001 |
|---|---|
| Synonyms | 3000002F19Rik; mKIAA2016; STEF |
| Vector | pRS |
| E. coli Selection | Ampicillin |
| Mammalian Cell Selection | Puromycin |
| Format | Retroviral plasmids |
| Components | Tiam2 - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 24001). 5µg purified plasmid DNA per construct29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free. |
| RefSeq | BC067048, BC079600, NM_001122998, NM_001286757, NM_001286758, NM_011878, NM_011878.1, NM_011878.2, NM_001122998.1, NM_001286758.1, NM_001286757.1 |
| UniProt ID | Q6ZPF3 |
| Summary | Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates specifically RAC1, but not CDC42 and RHOA. Mediates extracellular laminin signals to activate Rac1, contributing to neurite growth. Involved in lamellipodial formation and advancement of the growth cone of embryonic hippocampal neurons. Promotes migration of neurons in the cerebral cortex. When overexpressed, induces membrane ruffling accompanied by the accumulation of actin filaments along the altered plasma membrane.UniProtKB/Swiss-Prot Function |
| shRNA Design | These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service. |
| Storage | Store at -20°C |
| Shipping | Ambient |
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