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Nfe2l2 Mouse shRNA Plasmid (Locus ID 18024)

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SKU
TR515053
Nfe2l2 - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
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Specifications
Specifications
Product Data
Locus ID 18024
Synonyms Nr; Nrf2
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components Nfe2l2 - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 18024). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq BC026943, NM_010902, NR_132727, NM_010902.1, NM_010902.2, NM_010902.3, NM_010902.4, BC003340, BC057948
UniProt ID Q60795
Summary This gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. The encoded transcription factor regulates genes which contain antioxidant response elements (ARE) in their promoters; many of these genes encode proteins involved in response to injury and inflammation which includes the production of free radicals. provided by RefSeq, Sep 2015
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
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Documents
Resources

file-alt Citations

Oxidative stress-elicited YY1 potentiates antioxidative response via enhancement of NRF2-driven transcriptional activity: A potential neuronal defensive mechanism against ischemia/reperfusion cerebral injury
Liu, Guo, Zhao
Biomed. Pharmacother. (2018) 108, 698-706 DOI: 10.1016/j.biopha.2018.09.082
AI Summary: OriGene's NRF2-shRNA and Scrambled shRNA were used to generate SH-SY5Y cell lines with reduced NRF2 expression, enabling the study of NRF2's role in antioxidant defense mechanisms during cerebral ischemia/reperfusion injury.
Snippet: To establish the SH-SY5Y cells stably deprived of endogenous NRF2, cells were transfected with NRF2-shRNA or Scrambled shRNA (OriGene, Beijing, China) using ViaFect Transfection Reagent, followed by puromycin selection (1.0 μg/ml, Sigma-Aldrich)
Showing 1-1 of 1 papers.
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