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Flt1 Mouse shRNA Plasmid (Locus ID 14254)

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SKU
TR514364
Flt1 - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
2 Weeks*

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Specifications
Specifications
Product Data
Locus ID 14254
Synonyms AI323757; Flt-1; sFlt1; VEGFR-1; VEGFR1
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components Flt1 - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 14254). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq BC029674, NM_010228, NM_010228.1, NM_010228.2, NM_010228.3, NM_001363135, NM_010228.4
UniProt ID P35969
Summary Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. May play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells. Can promote endothelial cell proliferation, survival and angiogenesis in adulthood. Its function in promoting cell proliferation seems to be cell-type specific. Promotes PGF-mediated proliferation of endothelial cells, and proliferation of some types of cancer cells, but does not promote proliferation of normal fibroblasts. Has very high affinity for VEGFA and relatively low protein kinase activity; may function as a negative regulator of VEGFA signaling by limiting the amount of free VEGFA and preventing its binding to KDR. Modulates KDR signaling by forming heterodimers with KDR. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leading to the activation of phosphatidylinositol kinase and the downstream signaling pathway. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Phosphorylates SRC, YES1 and PLCG, and may also phosphorylate CBL. Promotes phosphorylation of AKT1 and PTK2/FAK1 (By similarity).UniProtKB/Swiss-Prot Function
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
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Documents
Resources

file-alt Citations

PRH/Hhex controls cell survival through coordinate transcriptional regulation of vascular endothelial growth factor signaling
Noy, Williams, Sawasdichai et al
Mol Cell Biol (2010) 30 (9), 2120-34 DOI: 10.1128/MCB.01511-09
AI Summary: In this paper, OriGene products—specifically the PRH/Hhex expression plasmid (RC211307) and PRH/Hhex shRNA (TG313293)—were used to manipulate PRH/Hhex levels in cells, enabling the authors to investigate how PRH regulates VEGF signaling and cell survival.
Showing 1-1 of 1 papers.
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