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Fzd5 Mouse shRNA Plasmid (Locus ID 14367)

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SKU
TR514012
Fzd5 - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
2 Weeks*

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Specifications
Specifications
Product Data
Locus ID 14367
Synonyms 5330434N09Rik; AI427138; Fz-5; Fz5; mFz5
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components Fzd5 - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 14367). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq BC117723, NM_001042659, NM_022721, NM_022721.1, NM_022721.2, NM_022721.3, NM_001042659.1
UniProt ID Q9EQD0
Summary Receptor for Wnt proteins (PubMed:11092808, PubMed:18230341). Can activate WNT2, WNT10B, WNT5A, but not WNT2B or WNT4 (in vitro); the in vivo situation may be different since not all of these are known to be coexpressed (PubMed:11092808). In neurons, activation of WNT7A promotes formation of synapses (By similarity). Functions in the canonical Wnt/beta-catenin signaling pathway (PubMed:18230341). The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (PubMed:18230341). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable). Plays a role in yolk sac angiogenesis and in placental vascularization (PubMed:11092808).UniProtKB/Swiss-Prot Function
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

Frizzled-5: a high affinity receptor for secreted frizzled-related protein-2 activation of nuclear factor of activated T-cells c3 signaling to promote angiogenesis
Peterson, Nasarre, Bonilla et al
Angiogenesis (2017)
AI Summary: OriGene products, specifically the HuSH shRNA plasmids targeting FZD5 and the pGFP-V-RS empty vector control, were used to stably silence FZD5 expression in endothelial cells, enabling the authors to demonstrate the necessity of FZD5 in SFRP2-induced angiogenic signaling.
Snippet: Stable transfection of 2H11 endothelial cells with FZD5 shRNA. To silence FZD5 in endothelial cells, we used HuSH shRNA plasmids containing FZD5 (OriGene, Rockville MD, USA). ... … Stable transfection of 2H11 endothelial cells with FZD5 shRNA. To silence FZD5 in endothelial cells, we used HuSH shRNA plasmids containing FZD5 (OriGene, Rockville MD, USA). ... …
Showing 1-1 of 1 papers.
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