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Rapgef3 Mouse shRNA Plasmid (Locus ID 223864)

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SKU
TR512817
Rapgef3 - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
2 Weeks*

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Specifications
Specifications
Product Data
Locus ID 223864
Synonyms 2310016P22Rik; 9330170P05Rik; Epac; Epac1
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components Rapgef3 - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 223864). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq BC020532, NM_001177810, NM_001177811, NM_144850, NM_001357630, NM_144850.1, NM_144850.2, NM_001177810.1, NM_001177811.1, BC020311
UniProt ID Q8VCC8
Summary Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which it activates the PI3K gamma complex and which is involved in angiogenesis. Plays a role in the modulation of the cAMP-induced dynamic control of endothelial barrier function through a pathway that is independent on Rho-mediated signaling. Required for the actin rearrangement at cell-cell junctions, such as stress fibers and junctional actin (By similarity).UniProtKB/Swiss-Prot Function
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

Pancreatic β-cell response to increased metabolic demand and to pharmacologic secretagogues requires EPAC2A
Song, Mondal, Li et al
Diabetes (2013) 62 (8), 2796-807 DOI: 10.2337/db12-1394
Cited by 50
AI Summary: OriGene’s murine EPAC1-specific shRNA lentiviral particles (TR512817) were used to selectively knock down EPAC1 in islets, enabling the study of EPAC2A’s specific role in β-cell insulin secretion and calcium dynamics.
Snippet: Scrambled and murine EPAC1-specific (TR512817, Origene) shRNA-expressing, purified (Virabind, Invitrogen) lentiviral particles (105) were spinoculated [41] twice in polybrene (2 mg/ml, Sigma) with islets After 3 days in culture, islet insulin secretion assays were performed
Showing 1-1 of 1 papers.
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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