Pmaip1 Mouse shRNA Plasmid (Locus ID 58801)
SKU
TR512752
Pmaip1 - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
$883.00
2 Weeks*
Specifications
| Product Data | |
| Locus ID | 58801 |
|---|---|
| Synonyms | Noxa |
| Vector | pRS |
| E. coli Selection | Ampicillin |
| Mammalian Cell Selection | Puromycin |
| Format | Retroviral plasmids |
| Components | Pmaip1 - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 58801). 5µg purified plasmid DNA per construct29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free. |
| RefSeq | BC050821, NM_021451, NM_021451.1, NM_021451.2 |
| UniProt ID | Q9JM54 |
| Summary | Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1 (By similarity). Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1.UniProtKB/Swiss-Prot Function |
| shRNA Design | These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service. |
| Storage | Store at -20°C |
| Shipping | Ambient |
Reviews
Documents
Resources
Citations
Noxa/HSP27 complex delays degradation of ubiquitylated IkBα in airway epithelial cells to reduce pulmonary inflammation
Zhang, Jones, Chand et al
Mucosal Immunol (2018)
Zhang, Jones, Chand et al
Mucosal Immunol (2018)
Cited by 10
AI Summary: OriGene’s retroviral silencing vectors encoding shHSP27, shNoxa, and the control vector (shCtrl) were used in this study to selectively suppress HSP27 and Noxa expression, enabling the investigation of their roles in regulating inflammation in airway epithelial cells.
Snippet: Article.;Retroviral silencing vector encoding shHSP27 or shNoxa and the corresponding control vector (shCtrl) were purchased from Origene Technologies, Inc., Rockville, MD. The suppressing effect of the shRNA was first established in AALEB cells and the subsequent amplification, purification, and packaging of the retroviral particles using Phoenix cells (Orbigen, Inc.) were performed as specified ...
Showing 1-1 of 1 papers.
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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