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Chtop Mouse shRNA Plasmid (Locus ID 66511)

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SKU
TR512568
Chtop - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
2 Weeks*

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Specifications
Specifications
Product Data
Locus ID 66511
Synonyms 2500003M10Rik; Fop; Srag
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components Chtop - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector (Gene ID = 66511). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq BC120651, NM_001293776, NM_001293777, NM_001293778, NM_001293779, NM_001293780, NM_001293781, NM_001293782, NM_023215, NM_023215.1, NM_023215.2, NM_023215.3, NM_023215.4, NM_023215.5, NM_023215.6, NM_001293781.1, NM_001293780.1, NM_001293779.1, NM_001293778.1, NM_001293782.1, NM_001293777.1, NM_001293776.1, BC004582, BC051939, BC066837, BC083333, BC108396, BC144775
UniProt ID Q9CY57
Summary Plays an important role in the ligand-dependent activation of estrogen receptor target genes (By similarity). May play a role in the silencing of fetal globin genes (PubMed:20688955). Recruits the 5FMC complex to ZNF148, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed:22872859). Required for the tumorigenicity of glioblastoma cells. Binds to 5-hydroxymethylcytosine (5hmC) and associates with the methylosome complex containing PRMT1, PRMT5, MEP50 and ERH. The CHTOP-methylosome complex associated with 5hmC methylates H4R3 and transactivates genes involved in glioblastomagenesis (PubMed:25284789).UniProtKB/Swiss-Prot Function
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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