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Siglece Mouse shRNA Plasmid (Locus ID 83382)

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SKU
TR512042
Siglece - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
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Specifications
Specifications
Product Data
Locus ID 83382
Synonyms Cd170; mSiglec-E; Siglec5; Siglec9; Siglec12; Siglecl1
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components Siglece - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 83382). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq BC023280, NM_031181, NM_031181.1, NM_031181.2
UniProt ID Q91Y57
Summary Putative adhesion molecule that mediates sialic-acid dependent binding to cells. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules.UniProtKB/Swiss-Prot Function
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

Siglec-E is up-regulated and phosphorylated following lipopolysaccharide stimulation in order to limit TLR-driven cytokine production
Boyd, Orr, Spence et al
J Immunol (2009) 183 (12), 7703-9 DOI: 10.4049/jimmunol.0902780
Cited by 78
AI Summary: In this study, OriGene products—specifically the Siglec-E expression plasmid (OriGene, MR207297) and Siglec-E shRNA (OriGene, TR506847)—were used to modulate Siglec-E expression in cells, enabling the authors to investigate Siglec-E’s role in regulating TLR-driven cytokine production.
FigureFigure
Showing 1-1 of 1 papers.
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