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Rcan1 Mouse shRNA Plasmid (Locus ID 54720)

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SKU
TR511392
Rcan1 - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
2 Weeks*

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Specifications
Specifications
Product Data
Locus ID 54720
Synonyms Adapt78; CALP1L; CSP1; DSC1; Dscr1; MCIP1; RCN1
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components Rcan1 - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 54720). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq BC013551, NM_001081549, NM_019466, NM_019466.1, NM_019466.2, NM_019466.3, NM_019466.4, NM_001081549.1, NM_001081549.2
UniProt ID Q9JHG6
Summary Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development (PubMed:11231093).UniProtKB/Swiss-Prot Function
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

Pyrrolidine dithiocarbamate (PDTC) inhibits inflammatory signaling via expression of regulator of calcineurin activity 1 (RCAN1): Anti-inflammatory mechanism of PDTC through RCAN1 induction
Lee, Kim, Seo
Biochem. Pharmacol. (2017)
AI Summary: OriGene’s pRS-RCAN1 shRNA expression vectors were used in this study to knock down RCAN1 expression, enabling the authors to demonstrate that PDTC’s anti-inflammatory effects are mediated through RCAN1 induction.
Snippet: SP600125 was purchased from Merck Millipore (Billerica, MA). U0126 and PD98059 were purchased from Calbiochem (Billerica, MA). A series of pRS-RCAN1 shRNA expression vectors were purchased from Origene (Rockville, MD, USA). 2.2. …SP600125 was purchased from Merck Millipore (Billerica, MA). U0126 and PD98059 were purchased from Calbiochem (Billerica, MA). A series of pRS-RCAN1 shRNA expression vectors were purchased from Origene (Rockville, MD, USA). 2.2. …
The regulator of calcineurin 1 (RCAN1/DSCR1) activates the cAMP response element-binding protein (CREB) pathway
Kim, Seo
J. Biol. Chem. (2011) 286 (43), 37841-8 DOI: 10.1074/jbc.M111.232165
Cited by 5
AI Summary: OriGene contributed to this study by providing the pRS-RCAN1 shRNA expression vector, which was used to investigate the role of RCAN1 in activating the CREB signaling pathway.
Snippet: called DSCR1, Adapt78, and MCIP) gene is located in the region of the Down syndrome critical region (DSCR) on human chromosome 21, the trisomy of which causes Down syndrome (DS ... The pRS-RCAN1 shRNA expression vector was purchased from Origene (Rockville, MD
Showing 1-2 of 2 papers.
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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