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Spry4 Mouse shRNA Plasmid (Locus ID 24066)

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SKU
TR509780
Spry4 - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
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Specifications
Specifications
Product Data
Locus ID 24066
Synonyms A030006O18Rik; sprouty4
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components Spry4 - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 24066). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq BC050944, BC057005, NM_011898, NM_011898.1, NM_011898.2, NM_011898.3
UniProt ID Q9WTP2
Summary Suppresses the insulin receptor and EGFR-transduced MAPK signaling pathway, but does not inhibit MAPK activation by a constitutively active mutant Ras. Probably impairs the formation of GTP-Ras (By similarity). Inhibits Ras-independent, but not Ras-dependent, activation of RAF1 (By similarity).UniProtKB/Swiss-Prot Function
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

Novel Function of Sprouty4 as a Regulator of Stemness and Differentiation of Embryonic Stem Cells
Lee, Park, Kim et al
Dev Reprod (2016) 20 (2), 171-7 DOI: 10.12717/DR.2016.20.2.171
FigureFigure
Suppression of Sproutys has a therapeutic effect for a mouse model of ischemia by enhancing angiogenesis
Taniguchi, Sasaki, Watari et al
PLoS One (2009) 4 (5), e5467 DOI: 10.1371/journal.pone.0005467
Cited by 41
AI Summary: OriGene’s Sprouty2 and Sprouty4 shRNA plasmids were used in this study to suppress Sprouty gene expression in vivo, enabling the researchers to demonstrate that knockdown of these genes enhances angiogenesis and improves recovery from ischemia in mice.
FigureFigureFigure
Showing 1-2 of 2 papers.
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