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Smad2 Mouse shRNA Plasmid (Locus ID 17126)

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SKU
TR509694
Smad2 - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
2 Weeks*

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Specifications
Specifications
Product Data
Locus ID 17126
Synonyms 7120426M23Rik; Madh2; Madr2; mMad2; Smad-2
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components Smad2 - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 17126). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq BC021342, BC089184, NM_001252481, NM_001311070, NM_010754, NM_010754.1, NM_010754.2, NM_010754.3, NM_010754.4, NM_001252481.1, BC058713, BM248478
UniProt ID Q62432
Summary Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator (By similarity).UniProtKB/Swiss-Prot Function
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

Suppression of canonical TGF-β signaling enables GATA4 to interact with H3K27me3 demethylase JMJD3 to promote cardiomyogenesis
Riching, Danis, Zhao et al
J Mol Cell Cardiol (2020) 153, 44-59 DOI: 10.1016/j.yjmcc.2020.12.005
Cited by 28
AI Summary: OriGene’s pRS-Smad2 shRNA constructs (TR509694) were used in this study to knock down Smad2 expression, enabling investigation of TGF-β signaling in cardiomyocyte reprogramming.
Snippet: oligonucleotides were purchased from IDT, amplified by PCR, and ligated into a modified pShagMagic2 miR-based vector, MSCV-PM (Addgene plasmid #27021 [66]). pRS-Smad2 shRNA constructs were purchased from Origene (TR509694). …
Adult cardiac stem cells are multipotent and robustly myogenic: c-kit expression is necessary but not sufficient for their identification
Vicinanza, Aquila, Scalise et al
Cell Death Differ. (2017)
AI Summary: OriGene contributed to this study by providing the Smad2 shRNA lentiviral vector (OriGene), which was used to disrupt TGF-β1-dependent SMAD signaling in c-kit positive cardiac stem cells.
Snippet: To distrupt TGF- β 1-dependent SMAD signalling, c-kit pos CSC were transfected with lentiviral vector carrying a shRNA specific for rat Smad2 with a GFP reporter (Smad2 shRNA , Origene, Rockville, MD, USA)
Showing 1-2 of 2 papers.
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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