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Spag5 Mouse shRNA Plasmid (Locus ID 54141)

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SKU
TR509034
Spag5 - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
2 Weeks*

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Specifications
Specifications
Product Data
Locus ID 54141
Synonyms AI874642; D11Bhm180e; Deepest; MAP126; Mastrin; S17
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components Spag5 - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 54141). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq BC052672, NM_017407, NM_017407.1, NM_017407.2, BC026715, NM_017407.3
UniProt ID Q7TME2
Summary Essential component of the mitotic spindle required for normal chromosome segregation and progression into anaphase. Required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture. In complex with SKAP, promotes stable microtubule-kinetochore attachments. May contribute to the regulation of separase activity. May regulate AURKA localization to mitotic spindle, but not to centrosomes and CCNB1 localization to both mitotic spindle and centrosomes. Involved in centriole duplication. Required for CDK5RAP22, CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2. In non-mitotic cells, upon stress induction, inhibits mammalian target of rapamycin complex 1 (mTORC1) association and recruits the mTORC1 component RPTOR to stress granules (SGs), thereby preventing mTORC1 hyperactivation-induced apoptosis. May enhance GSK3B-mediated phosphorylation of other substrates, such as MAPT/TAU (By similarity).UniProtKB/Swiss-Prot Function
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

DIAPH3 deficiency links microtubules to mitotic errors, defective neurogenesis, and brain dysfunction
Lau, Damiani, Chehade et al
Elife (2021) 10 DOI: 10.7554/eLife.61974
AI Summary: In this study, OriGene products including the SPAG5 Myc-DDK-tagged overexpression plasmid (RC210114) and SPAG5 shRNA plasmid (TG312498) were used to manipulate SPAG5 expression levels, enabling the authors to demonstrate that SPAG5 knockdown phenocopies DIAPH3 deficiency and that SPAG5 overexpression rescues DIAPH3 knockdown phenotypes.
FigureFigureFigure
Showing 1-1 of 1 papers.
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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