Hdac1 Mouse shRNA Plasmid (Locus ID 433759)
SKU
TR508815
Hdac1 - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
$883.00
In Stock*
Specifications
| Product Data | |
| Locus ID | 433759 |
|---|---|
| Synonyms | HD1; Hdac1-ps; MommeD5; RPD3 |
| Vector | pRS |
| E. coli Selection | Ampicillin |
| Mammalian Cell Selection | Puromycin |
| Format | Retroviral plasmids |
| Components | Hdac1 - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 433759). 5µg purified plasmid DNA per construct29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free. |
| RefSeq | BC092070, BC108371, NM_008228, NM_008228.1, NM_008228.2, BC092285 |
| UniProt ID | O09106 |
| Summary | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B. Deacetylates NR1D2 and abrogates the effect of KAT5-mediated relieving of NR1D2 transcription repression activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Involved in CIART-mediated transcriptional repression of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1 heterodimer. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex or CRY1 through histone deacetylation.UniProtKB/Swiss-Prot Function |
| shRNA Design | These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service. |
| Storage | Store at -20°C |
| Shipping | Ambient |
Reviews
Documents
Resources
Citations
A novel domain in histone deacetylase 1 and 2 mediates repression of cartilage-specific genes in human chondrocytes
Hong, Derfoul, Pereira-Mouries et al
FASEB J (2009) 23 (10), 3539-52 DOI: 10.1096/fj.09-133215
Hong, Derfoul, Pereira-Mouries et al
FASEB J (2009) 23 (10), 3539-52 DOI: 10.1096/fj.09-133215
Cited by 117
AI Summary: OriGene products contributed to this study by providing the HDAC1 and HDAC2 cDNA clones (Cat# SC119323 and SC119324), which were used for expression and functional analysis of these proteins in human chondrocytes.
Showing 1-1 of 1 papers.
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