Gfral Mouse shRNA Plasmid (Locus ID 404194)
Specifications
| Product Data | |
| Locus ID | 404194 |
|---|---|
| Synonyms | AY457637; Gral |
| Vector | pRS |
| E. coli Selection | Ampicillin |
| Mammalian Cell Selection | Puromycin |
| Format | Retroviral plasmids |
| Components | Gfral - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 404194). 5µg purified plasmid DNA per construct29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free. |
| RefSeq | NM_205844, NR_153419, NM_205844.1, NM_205844.2, NM_205844.3, BC141533, BC153094 |
| UniProt ID | Q6SJE0 |
| Summary | Brainstem-restricted receptor for GDF15 which regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses (PubMed:28953886, PubMed:28846099, PubMed:28846097, PubMed:28846098). Upon interaction with its ligand, GDF15, interacts with RET and induces cellular signaling through activation of MAPK- and AKT- signaling pathways (PubMed:28846098, PubMed:28846099).UniProtKB/Swiss-Prot Function |
| shRNA Design | These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service. |
| Storage | Store at -20°C |
| Shipping | Ambient |
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