Vps39 Mouse shRNA Plasmid (Locus ID 269338)
Specifications
| Product Data | |
| Locus ID | 269338 |
|---|---|
| Synonyms | A230065P22Rik; AW743070; mVam6; Vam6; Vam6P |
| Vector | pRS |
| E. coli Selection | Ampicillin |
| Mammalian Cell Selection | Puromycin |
| Format | Retroviral plasmids |
| Components | Vps39 - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 269338). 5µg purified plasmid DNA per construct29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free. |
| RefSeq | BC007479, NM_147153, NM_178851, NR_027618, NM_178851.1, NM_178851.2, NM_178851.3, NM_147153.2, NM_147153.3, BM249306, NM_001363053, NM_001363054, NM_178851.4, NM_147153.4 |
| UniProt ID | Q8R5L3 |
| Summary | May play a role in clustering and fusion of late endosomes and lysosomes (By similarity). Regulator of TGF-beta/activin signaling, inhibiting SMAD3- and activating SMAD2-dependent transcription. Acts by interfering with SMAD3/SMAD4 complex formation, this would lead to inhibition of SMAD3-dependent transcription and relieve SMAD3 inhibition of SMAD2-dependent promoters, thus increasing SMAD2-dependent transcription (By similarity).UniProtKB/Swiss-Prot Function |
| shRNA Design | These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service. |
| Storage | Store at -20°C |
| Shipping | Ambient |
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