D8Ertd82e Mouse shRNA Plasmid (Locus ID 244418)
Specifications
| Product Data | |
| Locus ID | 244418 |
|---|---|
| Synonyms | 9830148H23; D8Ertd82e; mFLJ00269; NACK; Sgk223 |
| Vector | pRS |
| E. coli Selection | Ampicillin |
| Mammalian Cell Selection | Puromycin |
| Format | Retroviral plasmids |
| Components | Prag1 - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector (Gene ID = 244418). 5µg purified plasmid DNA per construct29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free. |
| RefSeq | BC089024, NM_172911, NM_172911.1, NM_172911.2, NM_172911.3 |
| UniProt ID | Q571I4 |
| Summary | Catalytically inactive protein kinase that acts as a scaffold protein (By similarity). Functions as an effector of the small GTPase RND2, which stimulates RhoA activity and inhibits NGF-induced neurite outgrowth (By similarity). Promotes Src family kinase (SFK) signaling by regulating the subcellular localization of CSK, a negative regulator of these kinases, leading to the regulation of cell morphology and motility by a CSK-dependent mechanism (By similarity). Acts as a critical coactivator of Notch signaling (PubMed:25038227).UniProtKB/Swiss-Prot Function |
| shRNA Design | These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service. |
| Storage | Store at -20°C |
| Shipping | Ambient |
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