E430025E21Rik Mouse shRNA Plasmid (Locus ID 223593)
Specifications
| Product Data | |
| Locus ID | 223593 |
|---|---|
| Synonyms | AL022848; C76463; E430025E21Rik; Kiaa0196; mKIAA0196; strumpellin |
| Vector | pRS |
| E. coli Selection | Ampicillin |
| Mammalian Cell Selection | Puromycin |
| Format | Retroviral plasmids |
| Components | Washc5 - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector (Gene ID = 223593). 5µg purified plasmid DNA per construct29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free. |
| RefSeq | BC034070, BC040815, BC067035, NM_153548, NM_153548.1, NM_153548.2, BC034070.1, BC031364, NM_153548.3 |
| UniProt ID | Q8C2E7 |
| Summary | Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes seems to inhibit WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization, and which is involved in regulation of the fission of tubules that serve as transport intermediates during endosome sorting. May be involved in axonal outgrowth. Involved in cellular localization of ADRB2. Involved in cellular trafficking of BLOC-1 complex cargos such as ATP7A and VAMP7 (By similarity). Involved in cytokinesis and following polar body extrusion during oocyte meiotic maturation (PubMed:24998208).UniProtKB/Swiss-Prot Function |
| shRNA Design | These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service. |
| Storage | Store at -20°C |
| Shipping | Ambient |
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