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Mb21d1 Mouse shRNA Plasmid (Locus ID 214763)

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SKU
TR506419
Mb21d1 - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
2 Weeks*

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Specifications
Specifications
Product Data
Locus ID 214763
Synonyms E330016A19Rik; Mb21d1
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components Mb21d1 - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector (Gene ID = 214763). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq BC052196, NM_173386, NR_125721, NM_173386.1, NM_173386.3, NM_173386.4, NM_173386.5, BC005787, BC044854, BC145651, BC145653
UniProt ID Q8C6L5
Summary The protein encoded by this gene is a DNA binding cytosolic protein that catalyzes the synthesis of cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) after sensing the presence of DNA in the cytoplasm. cGAMP binds another protein, Stimulator of interferon genes (STING), leading to the induction of interferons, and a host immune response. Reduced expression of this gene inhibits interferon induction in the presence of some viral infections. Alternative splicing results in multiple transcript variants. provided by RefSeq, Jul 2014
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

Nucleic Acid Recognition Orchestrates the Anti-Viral Response to Retroviruses
Stavrou, Blouch, Kotla et al
Cell Host Microbe (2015)
Cited by 77
AI Summary: OriGene contributed to this study by providing the murine DDX41 plasmid, which was used to investigate the role of DDX41 in retroviral nucleic acid sensing and the antiviral response.
Snippet: … Murine DDX41 and cGAS plasmids were purchased from OriGene and Open Biosystems, respectively. A myc/his tag was introduced at the DDX41 C terminus by subcloning into pcDNA3.1myc/his (Invitrogen). A V5 tag was introduced at the cGAS C terminus by PCR. …
Showing 1-1 of 1 papers.
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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