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Adrbk1 Mouse shRNA Plasmid (Locus ID 110355)

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SKU
TR505928
Grk2 - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
2 Weeks*

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Specifications
Specifications
Product Data
Locus ID 110355
Synonyms Adrbk-1; Bark-1; beta ARK; betaARK1; GRK2
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components Grk2 - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector (Gene ID = 110355). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq BC053922, NM_001290818, NM_130863, NM_130863.1, NM_130863.2, NM_001290818.1, BC003196, BC033272, BC038312
UniProt ID Q99MK8
Summary Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner. Positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by faciltating the trafficking of SMO into the cilium and the stimulation of SMO activity.UniProtKB/Swiss-Prot Function
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

Osteogenesis is improved by low Tumour Necrosis factor-α concentration through the modulation of Gs-coupled receptor signals
Daniele, Natali, Giacomelli et al
Mol. Cell. Biol. (2017)
AI Summary: OriGene products, specifically the GRK2 plasmid and the corresponding empty vector, were used to manipulate GRK2 expression in mesenchymal stem cells, enabling the study of how TNF-α modulates osteogenesis through Gs-coupled receptor signaling.
Snippet: TNF-α. The, cells were incubated with 1 µg either of GRK2 plasmid (Origene, MD, USA) or the 170 corresponding empty vector (OriGene, MD, USA) for 30 h. Transfected MSCs were rapidly seeded 171 in 24 well plate and subjected to the cAMP assay, as described ... All 2 versions Cite SaveSaving
Showing 1-1 of 1 papers.
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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