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Usp8 Mouse shRNA Plasmid (Locus ID 84092)

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SKU
TR505445
Usp8 - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
2 Weeks*

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Specifications
Specifications
Product Data
Locus ID 84092
Synonyms AI574262; AW557536; mKIAA0055; Ubpy
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components Usp8 - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 84092). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq BC050947, BC061465, BC066126, NM_001252580, NM_019729, NM_019729.1, NM_019729.2, NM_019729.3, NM_001252580.1, BC027052, BC038123, BC092078
UniProt ID Q80U87
Summary Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. Converts both 'Lys-48' an 'Lys-63'-linked ubiquitin chains. Catalytic activity is enhanced in the M phase. Involved in cell proliferation. Required to enter into S phase in response to serum stimulation. May regulate T-cell anergy mediated by RNF128 via the formation of a complex containing RNF128 and OTUB1. Probably regulates the stability of STAM2 and RASGRF1. Regulates endosomal ubiquitin dynamics, cargo sorting, membrane traffic at early endosomes, and maintenance of ESCRT-0 stability. The level of protein ubiquitination on endosomes is essential for maintaining the morphology of the organelle. Deubiquitinates EPS15 and controles tyrosine kinase stability. Removes conjugated ubiquitin from EGFR thus regulating EGFR degradation and downstream MAPK signaling. Involved in acrosome biogenesis through interaction with the spermatid ESCRT-0 complex and microtubules. Deubiquitinates BIRC6/bruce and KIF23/MKLP1 (By similarity). Deubiquitinates BACE1 which inhibits BACE1 lysosomal degradation and modulates BACE-mediated APP cleavage and amyloid-beta formation (By similarity).UniProtKB/Swiss-Prot Function
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

USP8 Deubiquitinates SHANK3 to Control Synapse Density and SHANK3 Activity-dependent Protein Levels
Kerrisk Campbell, Sheng
J. Neurosci. (2018) 38 (23), 5289-5301 DOI: 10.1523/JNEUROSCI.3305-17.2018
AI Summary: OriGene products, including Myc-tagged rat USP8 cDNA and rat USP8 shRNA constructs, were used in this study to manipulate USP8 expression and investigate its role in regulating SHANK3 protein levels and synapse density.
Snippet: Human SHANK2 Myc-tagged pCMV, human GKAP pCMV, and Myc-tagged rat 119 USP8 cDNAs were purchased (OriGene Technologies) Rat USP8 shRNA constructs were purchased 121 (OriGene Technologies) and targeted the following sequences: USP8_A 122
Showing 1-1 of 1 papers.
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