Apobec3 Mouse shRNA Plasmid (Locus ID 80287)
SKU
TR505334
Apobec3 - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
$883.00
2 Weeks*
Specifications
| Product Data | |
| Locus ID | 80287 |
|---|---|
| Synonyms | Apobec; Arp3; BC003314; Cem15; Rfv3 |
| Vector | pRS |
| E. coli Selection | Ampicillin |
| Mammalian Cell Selection | Puromycin |
| Format | Retroviral plasmids |
| Components | Apobec3 - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 80287). 5µg purified plasmid DNA per construct29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free. |
| RefSeq | BC003314, NM_001160415, NM_001347041, NM_030255, NM_030255.1, NM_030255.2, NM_030255.3, NM_001160415.1, BC007182 |
| UniProt ID | Q99J72 |
| Summary | DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single-or double-stranded RNA. Exhibits antiviral activity against HIV-1, simian immunodeficiency viruses (SIVs), mouse mammary tumor virus (MMTV) and friend murine leukemia virus (FrMLV) and may inhibit the mobility of LTR retrotransposons.UniProtKB/Swiss-Prot Function |
| shRNA Design | These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service. |
| Storage | Store at -20°C |
| Shipping | Ambient |
Reviews
Documents
Resources
Citations
Oncolytic virotherapy induced CSDE1 neo-antigenesis restricts VSV replication but can be targeted by immunotherapy
Kottke, Tonne, Evgin et al
Nat Commun (2021) 12 (1), 1930 DOI: 10.1038/s41467-021-22115-1
Kottke, Tonne, Evgin et al
Nat Commun (2021) 12 (1), 1930 DOI: 10.1038/s41467-021-22115-1
Cited by 29
AI Summary: OriGene’s four unique 29mer shRNA retroviral constructs were used in this study to effectively knock down murine APOBEC3 expression in B16 cells, enabling the investigation of APOBEC3’s role in tumor escape from oncolytic virotherapy.
Snippet: e The CSDE1 gene was sequenced using the primer 5′-TCACGAAGTGCTGCTGAAGT-3′ and aligned with NCBI Reference Sequence: NM_144901.4. APOBEC3 knockdown Four unique 29mer shRNA retroviral constructs (Origene Technologies, Rockville, MD) were used as a combination to significantly reduce the expression of murine APOBEC3 in B16 cells compared to a single, scrambled shRNA encoding retroviral construc;Four unique 29mer shRNA retroviral constructs (Origene Technologies, Rockville, MD) were used as a combination to significantly reduce the expression of murine APOBEC3 in B16 cells compared to a single,
APOBEC3 Mediates Resistance to Oncolytic Viral Therapy
Huff, Wongthida, Kottke et al
Mol Ther Oncolytics (2018) 11, 1-13 DOI: 10.1016/j.omto.2018.08.003
Huff, Wongthida, Kottke et al
Mol Ther Oncolytics (2018) 11, 1-13 DOI: 10.1016/j.omto.2018.08.003
Cited by 24
AI Summary: OriGene products contributed to this study by providing the human APOBEC3B overexpression plasmid, which was used to assess the role of APOBEC3B in promoting resistance to oncolytic vesicular stomatitis virus (VSV) in cancer cells.
Showing 1-2 of 2 papers.
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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