Suz12 Mouse shRNA Plasmid (Locus ID 52615)
SKU
TR502902
Suz12 - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
$883.00
In Stock*
Specifications
| Product Data | |
| Locus ID | 52615 |
|---|---|
| Synonyms | 2610028O16Rik; AI195385; AU016842; AW536442; D11Ertd530; D11Ertd530e; mKIAA0160 |
| Vector | pRS |
| E. coli Selection | Ampicillin |
| Mammalian Cell Selection | Puromycin |
| Format | Retroviral plasmids |
| Components | Suz12 - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 52615). 5µg purified plasmid DNA per construct29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free. |
| RefSeq | BC064461, NM_001163018, NM_199196, NM_199196.1, NM_199196.2, NM_001163018.1, BC003922, BC031375, BC039915, BC051099, BC084591 |
| UniProt ID | Q80U70 |
| Summary | This gene encodes a core component of the polycomb repressive complex 2 (PRC2) that also includes, at least, embryonic ectoderm development protein (EED) and enhancer of zeste homolog 1 or 2 (EZH1 or EZH2). Through the methyltransferase activity of EZH1 or EZH2, the PRC2 complex methylates Lys9 and Lys27 of histone 3 and Lys26 of histone 1, leading to recruitment of the PRC1 complex, histone 2A ubiquitylation and transcriptional repression of the target genes. This gene product is essential for the activity and integrity of the PRC2 complex, and is required for X chromosome inactivation, stem cell maintenance and differentiation. Two transcript variants encoding different isoforms have been found for this gene. provided by RefSeq, Jul 2009 |
| shRNA Design | These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service. |
| Storage | Store at -20°C |
| Shipping | Ambient |
Reviews
Documents
Resources
Citations
Reduced H3K27me3 leads to abnormal Hox gene expression in neural tube defects
Yu, Wang, Pei et al
Epigenetics Chromatin (2019) 12 (1), 76 DOI: 10.1186/s13072-019-0318-1
Yu, Wang, Pei et al
Epigenetics Chromatin (2019) 12 (1), 76 DOI: 10.1186/s13072-019-0318-1
Cited by 51
AI Summary: OriGene’s Suz12 expression plasmid was used to overexpress Suz12 in F9 cells, enabling the authors to investigate its role in H3K27me3 regulation and HOX gene expression in neural tube defect models.
Snippet: a nonspecific siRNA 5′-TTCTCCGAACGTGTCACGT-3′ were designed and synthesized (Sangon Biotech, China), and the latter was transfected as negative control. Suz12 expression plasmid was purchase from Origene. After transfection for 24 h, F9 cells were treated with 1 μM RA for 24 h, and then harvested for further analysis. STATISTICAL ANALYSIS Statistical analysis was performed using SPSS sof
Showing 1-1 of 1 papers.
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