Pla2g10 Mouse shRNA Plasmid (Locus ID 26565)
Specifications
| Product Data | |
| Locus ID | 26565 |
|---|---|
| Synonyms | GX sPLA2; mGXs; PLA; PLA2GX; sPLA2-X |
| Vector | pRS |
| E. coli Selection | Ampicillin |
| Mammalian Cell Selection | Puromycin |
| Format | Retroviral plasmids |
| Components | Pla2g10 - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 26565). 5µg purified plasmid DNA per construct29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free. |
| RefSeq | BC028879, NM_001291009, NM_011987, NR_110990, NM_011987.1, NM_011987.2, NM_011987.3, NM_011987.4, NM_001291009.1, NM_001291009.2 |
| UniProt ID | Q9QXX3 |
| Summary | This gene encodes a member of the phospholipase A2 family of lipolytic enzymes that hydrolyzes glycerophospholipids to produce free fatty acids and lysophospholipids. The encoded protein undergoes proteolytic processing to generate a calcium-dependent enzyme that plays pivotal roles in the liberation of arachidonic acid from membrane phospholipids leading to the production of various inflammatory lipid mediators, such as prostaglandins. In response to myocardial ischemia/reperfusion, mice lacking the encoded protein display a reduction in myocardial infarct size partly through the suppression of neutorphil cytotoxic activities. Alternative splicing results in multiple transcript variants encoding different isoforms. All of these isoforms may undergo similar processing to generate the mature protein. provided by RefSeq, Jul 2015 |
| shRNA Design | These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service. |
| Storage | Store at -20°C |
| Shipping | Ambient |
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