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Tgfb1 Mouse shRNA Plasmid (Locus ID 21803)

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SKU
TR502269
Tgfb1 - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
2 Weeks*

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Specifications
Specifications
Product Data
Locus ID 21803
Synonyms TGF-beta; TGF-beta1; Tgfb; Tgfb-1; TGFbeta; TGFbeta1
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components Tgfb1 - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 21803). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq BC013738, NM_011577, NM_011577.1, NM_011577.2
UniProt ID P04202
Summary This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGF-beta family members. This encoded protein regulates cell proliferation, differentiation and growth, and can modulate expression and activation of other growth factors including interferon gamma and tumor necrosis factor alpha. Mice lacking a functional copy of this gene develop severe multifocal inflammatory disease, yolk sac defects and colon cancer. provided by RefSeq, Aug 2016
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

Lower-Molecular-Weight Chitosan-Treated Polyethyleneimine: a Practical Strategy For Gene Delivery to Mesenchymal Stem Cells
Liu, Zhang, Zhao et al
Cell. Physiol. Biochem. (2018) 50 (4), 1255-1269 DOI: 10.1159/000494585
AI Summary: OriGene contributed to this study by providing the TGF-β1-expressing plasmid, which was used to evaluate the gene delivery efficiency and functional effects of the novel chitosan-PEI (CP) gene delivery system in mesenchymal stem cells.
Snippet: All other chemicals were of analytical grade. A pGL3 plasmid coding for luciferase was kindly provided by the Institute of Infectious Diseases, Zhejiang University. A TGF-β1-expressing plasmid was purchased from OriGene Co. (Beijing, China)
Showing 1-1 of 1 papers.
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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