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Tead2 Mouse shRNA Plasmid (Locus ID 21677)

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SKU
TR502250
Tead2 - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
2 Weeks*

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Specifications
Specifications
Product Data
Locus ID 21677
Synonyms Etdf; ETF; TEAD-2; TEF-4; TEF4
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components Tead2 - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 21677). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq BC050217, NM_001285498, NM_001285500, NM_011565, NM_011565.1, NM_011565.2, NM_001285500.1, NM_001285498.1, BC020330, NM_001285498.2, NM_011565.3, NM_001285500.2
UniProt ID P48301
Summary Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction (By similarity). Binds to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3'). May be involved in the gene regulation of neural development. Binds to the M-CAT motif.UniProtKB/Swiss-Prot Function
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
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Documents
Resources

file-alt Citations

Transcription factors TEAD2 and E2A globally repress acetyl-CoA synthesis to promote tumorigenesis
Park, Mossmann, Chen et al
Mol Cell (2022) 82 (22), 4246-4261.e11 DOI: 10.1016/j.molcel.2022.10.027
Cited by 31
AI Summary: In this study, OriGene products—specifically the TEAD2 (Cat# SR307879) and E2A (Cat# SR305024) shRNA lentiviral particles—were used to knock down TEAD2 and E2A expression, enabling the authors to demonstrate that these transcription factors repress acetyl-CoA synthesis and thereby promote tumorigenesis.
Snippet: Transcription factors TEAD2 and E2A globally repress acetyl-CoA synthesis to promote tumorigenesis
Showing 1-1 of 1 papers.
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