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Sp1 Mouse shRNA Plasmid (Locus ID 20683)

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SKU
TR502115
Sp1 - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
2 Weeks*

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Specifications
Specifications
Product Data
Locus ID 20683
Synonyms 1110003E12Rik; AA450830; AI845540; Sp1-1
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components Sp1 - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 20683). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq NM_013672, NM_013672.1, NM_013672.2, BC165998
UniProt ID O89090
Summary Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR-alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter Plays an essential role in the regulation of FE65 gene expression (By similarity). Positively regulates the transcription of the core clock component ARNTL/BMAL1 (PubMed:24030830). Plays a role in protecting cells against oxidative stress following brain injury by regulating the expression of RNF112 (PubMed:27918959).UniProtKB/Swiss-Prot Function
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

Dual regulation of TERT activity through transcription and splicing by DeltaNP63alpha
Vorovich, Ratovitski
Aging (Albany NY) (2008) 1 (1), 58-67 DOI: 10.18632/aging.100003
Cited by 10
AI Summary: OriGene products, specifically the p63 (NM_003722) cDNA clone and SIRT1 (NM_012238) cDNA clone, were used for overexpression studies to investigate how DeltaNp63alpha regulates TERT activity through both transcriptional and splicing mechanisms in mouse and human keratinocytes.
FigureFigureFigure
Showing 1-1 of 1 papers.
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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