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Ptpn11 Mouse shRNA Plasmid (Locus ID 19247)

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SKU
TR501795
Ptpn11 - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
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Specifications
Specifications
Product Data
Locus ID 19247
Synonyms 2700084A17Rik; AW536184; PTP1D; PTP2C; SAP-2; SH-PTP2; SH-PTP3; SHP-2; Shp2; Syp
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components Ptpn11 - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 19247). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq BC057398, BC059278, NM_001109992, NM_011202, NM_011202.1, NM_011202.2, NM_011202.3, NM_001109992.1, BC003980, BC028513, BM899214
UniProt ID P35235
Summary Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Positively regulates MAPK signal transduction pathway. Dephosphorylates GAB1, ARHGAP35 and EGFR. Dephosphorylates ROCK2 at 'Tyr-722' resulting in stimulatation of its RhoA binding activity. Dephosphorylates CDC73.UniProtKB/Swiss-Prot Function
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

The protein tyrosine phosphatase, Shp2, positively contributes to FLT3-ITD-induced hematopoietic progenitor hyperproliferation and malignant disease in vivo
Nabinger, Li, Ramdas et al
Leukemia (2013) 27 (2), 398-408 DOI: 10.1038/leu.2012.308
Cited by 57
AI Summary: OriGene’s Shp2-specific shRNA and scrambled shRNA were used to knock down Shp2 expression, enabling the authors to assess Shp2’s role in FLT3-ITD-induced cell proliferation and leukemia progression.
Snippet: were transfected with a vector encoding U6 polymerase III–directed Shp2-specific short-hairpin RNA (shRNA) or scrambled shRNA (Origene, Rockville, MD ... MV411 cells serve as a good model as they are derived from a human sample, express FLT3-ITD under endogeneous
Showing 1-1 of 1 papers.
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