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Psme3 Mouse shRNA Plasmid (Locus ID 19192)

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SKU
TR501768
Psme3 - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
2 Weeks*

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Specifications
Specifications
Product Data
Locus ID 19192
Synonyms AA410043; AU020960; Ki; pa28g; PA28gamma; REGgamma
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components Psme3 - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 19192). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq BC015255, BC139818, NM_011192, NM_011192.1, NM_011192.2, NM_011192.3, BC005524, NM_011192.4
UniProt ID P61290
Summary Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regulation. Mediates CCAR2 and CHEK2-dependent SIRT1 inhibition (By similarity).UniProtKB/Swiss-Prot Function
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

REGγ controls Hippo signaling and reciprocal NF-κB-YAP regulation to promote colon cancer
Li, Wang, Gao et al
Clin. Cancer Res. (2018)
AI Summary: OriGene’s retroviral shRNA vectors targeting REGγ were used to generate REGγ-deficient colon cancer cell lines, enabling the study of REGγ’s role in Hippo and NF-κB signaling in colorectal cancer.
Snippet: penicillin/streptomycin. HCT116 sh-N, HCT116 sh-R, HT29 sh-N, HT29 sh-R cells were generated by retroviral shRNA vectors specific for REGγ or a control vector from OriGene (Rockville, MD). The 293- REGγ inducible cell line and MEF SV40 WT, MEF
Showing 1-1 of 1 papers.
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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