Naca Mouse shRNA Plasmid (Locus ID 17938)
Specifications
| Product Data | |
| Locus ID | 17938 |
|---|---|
| Synonyms | AL022831; AL024382; Gm1878; mKIAA0363; skNAC |
| Vector | pRS |
| E. coli Selection | Ampicillin |
| Mammalian Cell Selection | Puromycin |
| Format | Retroviral plasmids |
| Components | Naca - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 17938). 5µg purified plasmid DNA per construct29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free. |
| RefSeq | BC083340, BC099375, NM_001113199, NM_001282976, NM_013608, NM_013608.1, NM_013608.2, NM_013608.3, NM_001113199.1, NM_001282976.1, BC029830 |
| UniProt ID | Q60817 |
| Summary | Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites) (By similarity). Isoform 1 and isoform 2 appear to bind DNA and play roles in transcription. Isoform 1 may function as a specific coactivator for JUN, acting to stabilize the interaction of JUN homodimers with promoter elements.UniProtKB/Swiss-Prot Function |
| shRNA Design | These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service. |
| Storage | Store at -20°C |
| Shipping | Ambient |
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