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Il6st Mouse shRNA Plasmid (Locus ID 16195)

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SKU
TR501089
Il6st - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
2 Weeks*

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Specifications
Specifications
Product Data
Locus ID 16195
Synonyms 5133400A03Rik; AA389424; BB405851; CD130; D13Ertd699e; gp130
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components Il6st - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 16195). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq BC058679, NM_010560, NM_010560.1, NM_010560.2, NM_010560.3, BC009665, BC020454, BC049887, BC058551
UniProt ID Q00560
Summary Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize IL6ST for initiating signal transmission. Binding of IL6 to IL6R induces IL6ST homodimerization and formation of a high-affinity receptor complex, which activates Janus kinases (PubMed:1602143). That causes phosphorylation of IL6ST tyrosine residues which in turn activates STAT3 (PubMed:10661409). Mediates signals which regulate immune response, hematopoiesis, pain control and bone metabolism (PubMed:10661409, PubMed:26255596, PubMed:25057188, PubMed:8552649). Has a role in embryonic development (PubMed:10661409). Does not bind IL6 (By similarity). Essential for survival of motor and sensory neurons and for differentiation of astrocytes (PubMed:10377352). Required for expression of TRPA1 in nociceptive neurons (PubMed:25057188). Required for the maintenance of PTH1R expression in the osteoblast lineage and for the stimulation of PTH-induced osteoblast differentiation (PubMed:25228504). Required for normal trabecular bone mass and cortical bone composition (PubMed:24339143, PubMed:9348227, PubMed:26255596).UniProtKB/Swiss-Prot Function
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

Modulation of cytokine receptors by IL-2 broadly regulates differentiation into helper T cell lineages
Liao, Lin, Wang et al
Nat. Immunol. (2011) 12 (6), 551-9 DOI: 10.1038/ni.2030
Cited by 473
AI Summary: OriGene contributed plasmids pRV-mIl6ra and pRV-mIl6st, which were used for retroviral transduction to study the role of IL-6 receptor components in helper T cell differentiation.
Snippet: taining. The plasmids pRV-mIl6ra and pRV-mIl6st were generated by Origene
FigureFigureFigure
Showing 1-1 of 1 papers.
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