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Gja1 Mouse shRNA Plasmid (Locus ID 14609)

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SKU
TR500808
Gja1 - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
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Specifications
Specifications
Product Data
Locus ID 14609
Synonyms AU042049; AW546267; Cnx43; connexin43; Cx43; Cx43alpha1; Gja-1; Npm1
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components Gja1 - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 14609). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq BC006894, BC055375, NM_010288, NM_010288.1, NM_010288.2, NM_010288.3, BC011324
UniProt ID P23242
Summary Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract. May play a role in cell growth inhibition through the regulation of NOV expression and localization (PubMed:15181016). Plays an essential role in gap junction communication in the ventricles (PubMed:26403541).UniProtKB/Swiss-Prot Function
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

Gap junctions/hemichannels modulate interkinetic nuclear migration in the forebrain precursors
Liu, Hashimoto-Torii, Torii et al
J Neurosci (2010) 30 (12), 4197-209 DOI: 10.1523/JNEUROSCI.4187-09.2010
AI Summary: OriGene’s Cx43 shRNA (sc-36200-SH) was used in this study to mediate knockdown of connexin 43, enabling the authors to investigate its role in regulating interkinetic nuclear migration in forebrain precursors.
Showing 1-1 of 1 papers.
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