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Gata4 Mouse shRNA Plasmid (Locus ID 14463)

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SKU
TR500773
Gata4 - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
2 Weeks*

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Specifications
Specifications
Product Data
Locus ID 14463
Synonyms Gata-4
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components Gata4 - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 14463). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq NM_001310610, NM_008092, NM_008092.1, NM_008092.2, NM_008092.3, NM_008092.4, BC137824
UniProt ID Q08369
Summary Transcriptional activator that binds to the consensus sequence 5'-AGATAG-3' and plays a key role in cardiac development (By similarity). In cooperation with TBX5, it binds to cardiac super-enhancers and promotes cardiomyocyte gene expression, while it downregulates endocardial and endothelial gene expression (By similarity). Involved in bone morphogenetic protein (BMP)-mediated induction of cardiac-specific gene expression (By similarity). Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions (By similarity). Acts as a transcriptional activator of ANF in cooperation with NKX2-5 (PubMed:9584153). Promotes cardiac myocyte enlargement (By similarity). Required during testicular development (By similarity). May play a role in sphingolipid signaling by regulating the expression of sphingosine-1-phosphate degrading enzyme, spingosine-1-phosphate lyase (By similarity).UniProtKB/Swiss-Prot Function
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

GATA-4 upregulates glucose-dependent insulinotropic polypeptide expression in cells of pancreatic and intestinal lineage
Jepeal, Boylan, Michael Wolfe
Mol Cell Endocrinol (2008) 287 (1-2), 20-9 DOI: 10.1016/j.mce.2008.01.024
Cited by 24
AI Summary: In this study, OriGene products—including GIP cDNA (OriGene, MC204727) and GATA-4 shRNA (OriGene, TG313392)—were used to manipulate gene expression in cell lines, enabling the authors to investigate the regulatory role of GATA-4 in glucose-dependent insulinotropic polypeptide (GIP) expression.
FigureFigure
Showing 1-1 of 1 papers.
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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