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Ccr4 Mouse shRNA Plasmid (Locus ID 12773)

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SKU
TR500386
Ccr4 - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
In Stock*

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Specifications
Specifications
Product Data
Locus ID 12773
Synonyms C-C CKR-4; CHEMR1; Cmkbr4; LESTR; Sdf1r
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components Ccr4 - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 12773). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq BC117041, BC119171, NM_009916, NM_009916.1, NM_009916.2
UniProt ID P51680
Summary High affinity receptor for the C-C type chemokines CCL17/TARC and CCL22/MDC. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Could play a role in lipopolysaccharide (LPS)-induced endotoxic shock. In the CNS, could mediate hippocampal-neuron survival.UniProtKB/Swiss-Prot Function
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

A CCR4 antagonist reverses the tumor-promoting microenvironment of renal cancer
Berlato, Khan, Schioppa et al
J. Clin. Invest. (2017) 127 (3), 801-813 DOI: 10.1172/JCI82976
AI Summary: OriGene products contributed to this study by providing commercially available shRNAs (TR314127 for human CCR4 and TR500386 for mouse CCR4) used to specifically target and knock down CCR4 expression in experimental models.
Snippet: Commercially available shRNAs, based on the pRS vector, were purchased from Origene Technologies. Four non-overlapping sequences were provided to target human (TR314127) and mouse (TR500386) CCR4
Showing 1-1 of 1 papers.
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