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Arf6 Mouse shRNA Plasmid (Locus ID 11845)

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SKU
TR500130
Arf6 - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
2 Weeks*

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Specifications
Specifications
Product Data
Locus ID 11845
Synonyms AI788669; AW496366
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components Arf6 - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 11845). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq BC003478, BC083112, NM_007481, NM_007481.1, NM_007481.2, NM_007481.3
UniProt ID P62331
Summary GTP-binding protein involved in protein trafficking that regulates endocytic recycling and cytoskeleton remodeling (PubMed:11950392). Required for normal completion of mitotic cytokinesis. Involved in the regulation of dendritic spine development, contributing to the regulation of dendritic branching and filopodia extension. Plays an important role in membrane trafficking, during junctional remodeling and epithelial polarization. Regulates surface levels of adherens junction proteins such as CDH1 (PubMed:29420262, PubMed:20080746). Required for NTRK1 sorting to the recycling pathway from early endosomes (By similarity).UniProtKB/Swiss-Prot Function
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

A critical role of Arf6 in the response of commissural axons to Slit
Kinoshita-Kawada, Hasegawa, Hongu et al
Development (2019)
AI Summary: OriGene products contributed shRNAs against mouse Cyth1, Cyth2, Cyth3, Arf6, and a control shRNA (all in pRS shRNA vector), which were used for ex vivo electroporation to investigate the roles of these genes in commissural axon response to Slit.
Snippet: siCyth2 (Silencer Select, Ambion/Thermo Fisher Scientific) was as previously described (Li et al., 2012). For ex vivo electroporation into spinal cords, shRNAs against mouse Cyth1, Cyth2, Cyth3 and Arf6 (in pRS shRNA vector;Origene) were used. Control shRNA (shControl) was also obtained from Origene
Showing 1-1 of 1 papers.
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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