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WNK3 Human shRNA Plasmid Kit (Locus ID 65267)

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SKU
TR320730
WNK3 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
2 Weeks*

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Specifications
Specifications
Product Data
Locus ID 65267
Synonyms PRKWNK3
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components WNK3 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 65267). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq NM_001002838, NM_020922, NM_020922.1, NM_020922.2, NM_020922.3, NM_020922.4, NM_001002838.1, NM_001002838.2, NM_001002838.3, BC156469, NM_001002838.4
UniProt ID Q9BYP7
Summary This gene encodes a protein belonging to the 'with no lysine' family of serine-threonine protein kinases. These family members lack the catalytic lysine in subdomain II, and instead have a conserved lysine in subdomain I. This family member functions as a positive regulator of the transcellular Ca2+ transport pathway, and it plays a role in the increase of cell survival in a caspase-3-dependent pathway. Alternative splicing results in multiple transcript variants. provided by RefSeq, May 2010
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

With-No-Lysine Kinase 3 (WNK3) stimulates glioma invasion by regulating cell volume
Haas, Cuddapah, Watkins et al
Am. J. Physiol., Cell Physiol. (2011) 301 (5), C1150-60 DOI: 10.1152/ajpcell.00203.2011
Cited by 65
AI Summary: OriGene contributed to this study by providing the shRNA constructs (RS vector targeting WNK3 and nonsilencing control) used to achieve stable knockdown of WNK3, enabling the authors to investigate WNK3's role in glioma cell invasion and volume regulation.
Snippet: Ions must be concentrated intracellularly to favor their efflux down electrochemical gradients to provide this function, and previous research ... RS vector containing either a nonsilencing, scrambled sequence (NS) or one of four sequences targeting WNK3 (Origene, Rockville, MD).
Showing 1-1 of 1 papers.
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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