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PTP4A3 Human shRNA Plasmid Kit (Locus ID 11156)

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SKU
TR320652
PTP4A3 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
In Stock*

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Specifications
Specifications
Product Data
Locus ID 11156
Synonyms PRL-3; PRL-R; PRL3
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components PTP4A3 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 11156). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq BC003105, NM_007079, NM_032611, NM_032611.1, NM_007079.1, NM_007079.2, NM_007079.3, BC003105.1
UniProt ID O75365
Summary This gene encodes a member of the protein-tyrosine phosphatase family. Protein tyrosine phosphatases are cell signaling molecules that play regulatory roles in a variety of cellular processes. Studies of this class of protein tyrosine phosphatase in mice demonstrates that they are prenylated in vivo, suggesting their association with cell plasma membrane. The encoded protein may enhance cell proliferation, and overexpression of this gene has been implicated in tumor metastasis. Alternative splicing results in multiple transcript variants. provided by RefSeq, Jul 2013
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

PRL-3 activates mTORC1 in Cancer Progression
Ye, Al-Aidaroos, Park et al
Sci Rep (2015) 5, 17046 DOI: 10.1038/srep17046
Cited by 29
AI Summary: OriGene’s PRL-3-targeting shRNA constructs were used to generate HCT116 cell lines with reduced PRL-3 expression, enabling the study of PRL-3’s role in activating mTORC1 in cancer progression.
Snippet: 1 mg/mL) for 2 weeks. HCT116 cells stably expressing scrambled or PRL-3-targeting shNA constructs (Origene Rockville, MD, USA) were generated by puromycin selection (1 μg/mL) for 2 weeks. Cells were grown in RPMI-1640 ... Cite SaveSaving
FigureFigureFigure
PRL-3 suppresses c-Fos and integrin α2 expression in ovarian cancer cells
Liu, Al-aidaroos, Wang et al
BMC Cancer (2013) 13, 80 DOI: 10.1186/1471-2407-13-80
Cited by 19
AI Summary: OriGene’s PRL-3 shRNA constructs (catalogue #TR320652) were used to stably knock down PRL-3 expression in A2780 ovarian cancer cells, enabling the study of PRL-3’s role in cancer cell migration, invasion, and tumorigenicity.
Snippet: Generation of stable cell lines. For PRL-3 knockdown, 8 shRNA constructs against human PRL-3 purchased from OriGene (catalogue #TR320652) and SABiosciences (catalogue #KH09221) were used to knock down PRL-3 in A2780 cells.
FigureFigureFigure
Showing 1-2 of 2 papers.
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