ZAP70 Human shRNA Plasmid Kit (Locus ID 7535)
Specifications
| Product Data | |
| Locus ID | 7535 |
|---|---|
| Synonyms | ADMIO2; IMD48; SRK; STCD; STD; TZK; ZAP-70 |
| Vector | pRS |
| E. coli Selection | Ampicillin |
| Mammalian Cell Selection | Puromycin |
| Format | Retroviral plasmids |
| Components | ZAP70 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 7535). 5µg purified plasmid DNA per construct29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free. |
| RefSeq | NM_001079, NM_207519, NM_207519.1, NM_001079.2, NM_001079.3, BC039039, BC039039.1, BC053878, BC053878.1, NM_207519.2, NM_001079.4 |
| UniProt ID | P43403 |
| Summary | This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. provided by RefSeq, Jul 2008 |
| shRNA Design | These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service. |
| Storage | Store at -20°C |
| Shipping | Ambient |
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