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TLR2 Human shRNA Plasmid Kit (Locus ID 7097)

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SKU
TR320553
TLR2 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
In Stock*

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Specifications
Specifications
Product Data
Locus ID 7097
Synonyms CD282; TIL4
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components TLR2 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 7097). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq NM_001318787, NM_001318789, NM_001318790, NM_001318791, NM_001318793, NM_001318795, NM_001318796, NM_003264, NM_003264.1, NM_003264.2, NM_003264.3, NM_003264.4, BC033756, BC033756.1, NM_003264.5
UniProt ID O60603
Summary The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. This protein is a cell-surface protein that can form heterodimers with other TLR family members to recognize conserved molecules derived from microorganisms known as pathogen-associated molecular patterns (PAMPs). Activation of TLRs by PAMPs leads to an up-regulation of signaling pathways to modulate the host's inflammatory response. This gene is also thought to promote apoptosis in response to bacterial lipoproteins. This gene has been implicated in the pathogenesis of several autoimmune diseases. Alternative splicing results in multiple transcript variants. provided by RefSeq, Jan 2016
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
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Documents
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Plasmodium falciparum Histidine-Rich Protein II Compromises Brain Endothelial Barriers and May Promote Cerebral Malaria Pathogenesis
Pal, Daniels, Oskman et al
MBio (2016) 7 (3) DOI: 10.1128/mBio.00617-16
AI Summary: OriGene products contributed to this study by providing shRNAs targeting Myd88 (TG311320), NFκB (TR318700), caspase-1 (TG305640), TLR9 (TR301076), TLR5 (TR308792), and TLR2 (TR320553), which were used to investigate the molecular pathways involved in HRPII-induced disruption of brain endothelial barriers.
Snippet: Cells were then incubated for 36 h. HRPII was then added, and TEER measurements were recorded over 24 h. shRNAs for each gene were purchased from Origene as follows: for the Myd88 gene, TG311320;for the NFκB gene, TR318700;for the caspase-1 gene, TG305640;for the TLR9 gene, TR301076;for the TLR5 gene, TR308792;and for the TLR2 gene, TR320553
The Role of Histidine Rich Protein II in Cerebral Malaria
Pal
Thesis (2017)
Snippet: …shRNAs for each gene were purchased from Origene : Myd88 (TG311320), NFкB (TR318700), Caspase-1 (TG305640), TLR9 (TR301076), TLR5 (TR308792), TLR2 (TR320553);of the four shRNAs received from the vendor, 2-3 were used based on silencing efficiency in pilot studies
The Role of Histidine Rich Protein II in Cerebral Malaria Pathogenesis
Pal
Thesis (2017)
Snippet: shRNAs for each gene were purchased from Origene : Myd88 (TG311320), NFB (TR318700), Caspase-1 (TG305640), TLR9 (TR301076), TLR5 (TR308792), TLR2 (TR320553);of the four shRNAs received from the vendor, 2-3 were used based on silencing efficiency ... Cite SaveSaving
Showing 1-3 of 3 papers.
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