Rb (RB1) Human shRNA Plasmid Kit (Locus ID 5925)

SKU
TR320511
RB1 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
In Stock*
Specifications
Specifications
Product Data
Locus ID 5925
Synonyms OSRC; p105-Rb; p110-RB1; pp110; PPP1R130; pRb; RB
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components RB1 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 5925). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq NM_000321, NM_000321.1, NM_000321.2, BC040540, BC040540.1, BC039060, NM_000321.3
UniProt ID P06400
Summary The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. provided by RefSeq, Jul 2008
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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