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MEK3 (MAP2K3) Human shRNA Plasmid Kit (Locus ID 5606)

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SKU
TR320491
MAP2K3 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
2 Weeks*

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Specifications
Specifications
Product Data
Locus ID 5606
Synonyms MAPKK3; MEK3; MKK3; PRKMK3; SAPKK-2; SAPKK2
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components MAP2K3 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 5606). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq NM_001316332, NM_002756, NM_145109, NM_145110, NM_145109.1, NM_145109.2, NM_002756.1, NM_002756.2, NM_002756.3, NM_002756.4, NM_145110.1, BC032478, BC032478.1, BM836867, NM_145109.3
UniProt ID P46734
Summary The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene. provided by RefSeq, Jul 2008
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
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Documents
Resources

file-alt Citations

The survival kinase Mirk/dyrk1B is activated through Rac1-MKK3 signaling
Jin, Lim, Mercer et al
J Biol Chem (2005) 280 (51), 42097-105 DOI: 10.1074/jbc.M507301200
AI Summary: In this study, OriGene products were used to facilitate gene knockdown and expression experiments, specifically employing OriGene’s MKK3 shRNA (catalog # TF311741) and Mirk/dyrk1B expression plasmid (catalog # SC119181) to investigate the Rac1-MKK3-Mirk signaling pathway in tumor cell survival.
Showing 1-1 of 1 papers.
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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