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AMPK alpha 2 (PRKAA2) Human shRNA Plasmid Kit (Locus ID 5563)

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SKU
TR320462
PRKAA2 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
In Stock*

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Specifications
Specifications
Product Data
Locus ID 5563
Synonyms AMPK; AMPK2; AMPKa2; PRKAA
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components PRKAA2 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 5563). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq NM_006252, NM_006252.1, NM_006252.2, NM_006252.3, BC069680, BC069680.1, BC043195, BC069740, BC069823, BM979925, NM_006252.4
UniProt ID P54646
Summary The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia. provided by RefSeq, Jul 2008
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

AMPK protects proximal tubular cells from stress-induced apoptosis by an ATP-independent mechanism: potential role of Akt activation
Lieberthal, Zhang, Patel et al
Am. J. Physiol. Renal Physiol. (2011) 301 (6), F1177-92 DOI: 10.1152/ajprenal.00034.2011
Cited by 37
AI Summary: OriGene's HuSH pRS plasmid vectors were used to deliver shRNA for gene silencing of the AMPK α2-catalytic subunit, enabling the study of AMPK's role in protecting kidney cells from stress-induced apoptosis.
Snippet: RNA interference with “short hairpin” RNA (shRNA) was used to “knock down” expression of the α2-catalytic subunit of AMPK. HuSH pRS plasmid vectors were purchased from Origene (Rockville, MD) and used according to the manufacturer's instructions.
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